Modulatory Role of Inulin Extract against Metabolic and Structural Changes in the Ovaries and Uterus of Induced Diabetic Albino Rats

Background: Chronic hyperglycemia is associated with long-term damage in the structure and functions of female gonads, especially ovaries uterus. Inulin major component Chicory (Cichorium intybus L.) roots leaves. used to prepare appropriate low caloric foods for diabetic patients maintain blood sugar levels. Aim: This work was mainly designed evaluate ameliorative role inulin extract on metabolic structural changes uterus rats neonatally induced by streptozotocin. Material methods: Twenty-four offsprings were present separated into 4 groups (n=6). Group 1: control group, group 2: supplemented (10mg /kgbw), 3: streptozotocin-induced that subjected a single intraperitoneal dose streptozotocin (80 mg/Kgbw), 4: Streptozotocin plus extract. Body weight, levels sex hormones, antioxidants, lipid profiles measured. Also, ovarian uterine specimens also processed histological immunohistochemical investigation Results: The obtained results revealed remarkable significant decrease serum antioxidants (superoxide dismutase catalase) hormones as well increase group. Moreover, several histopathological signs appeared sections including, atretic follicles, degenerated germinal epithelium, stromal hemorrhage, fragmented endometrial glands, cellular hypertrophy. Furthermore, displayed strong positive expression NFκB showed weak B-cell lymphoma-2 if compared control. Conclusion: has potential amelioration disrupted through exerting hypoglycemic, hypolipidemic, antioxidant, anti-apoptotic effects modulation hormones.